Scientific Applications

Our technology has been proven in various fields of research, from DNA repair to small molecule detection.

Case Studies

IgG Binding Kinetics

Protein-Protein Interactions

Real-time monitoring of Rabbit IgG binding to Anti-Rabbit IgG. The sensor simultaneously registers adlayer thickness changes (binding) and bulk RI changes.

Volume RI Detection

Volume RI Detection

High-sensitivity detection of Refractive Index changes in bulk solution (e.g., Ethanol injections) using the EVA 3.0 imaging biosensor.

Selected Publications

DNA Repair Protein Interaction

Nifontova, G., et al. (2024). Photonic Crystal Surface Mode Real-Time Imaging of RAD51 DNA Repair Protein Interaction with the ssDNA Substrate. Biosensors, 14(1), 43.

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Small Molecule Detection

Shakurov, R., et al. (2023). Dendrimer-Based Coatings on a Photonic Crystal Surface for Ultra-Sensitive Small Molecule Detection. Polymers, 15(12), 2607.

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Multiplexed Label-Free Biosensing

Konopsky, V., et al. (2020). Photonic crystal surface mode imaging for multiplexed and high-throughput label-free biosensing. Biosensors and Bioelectronics, 168, 112575.

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Multiplex Biosensing of Cancer Biomarkers

Petrova, I., et al. (2019). Label-free flow multiplex biosensing via photonic crystal surface mode detection. Scientific Reports, 9, 8745.

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Foundation of PC SM Imaging

Konopsky, V. N., & Alieva, E. V. (2018). Photonic crystal surface mode imaging biosensor based on wavelength interrogation of resonance peak. Sensors and Actuators B: Chemical, 276, 271-278.

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Antibody Binding to Bacteria

Rostova, E., et al. (2016). Kinetics of Antibody Binding to Membranes of Living Bacteria Measured by a Photonic Crystal-Based Biosensor. Biosensors, 6(4), 52.

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High-Throughput Protein Array Analysis

Nifontova, G., et al. (2023). Label-Free Multiplexed Microfluidic Analysis of Protein Interactions Based on Photonic Crystal Surface Mode Imaging. International Journal of Molecular Sciences, 24(5), 4347.

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Photonic Crystal Chips for Optical Biosensors

Sizova, S., et al. (2022). The Elaboration of Effective Coatings for Photonic Crystal Chips in Optical Biosensors. Polymers, 14(1), 152.

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Early Dual-Interrogation PC Biosensor

Konopsky, V., et al. (2013). Photonic Crystal Biosensor Based on Optical Surface Waves. Sensors, 13(2), 2566-2578.

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Original Dual-Mode registration Concept

Konopsky, V. N., & Alieva, E. V. (2007). Photonic crystal surface waves for optical biosensors. Analytical Chemistry, 79(12), 4729-4735.

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